Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics

Protein instability is a major obstacle in the production and delivery of monoclonal antibody–based therapies for cancer. This study presents real-time isothermal differential scanning fluorimetry as an emerging method to evaluate the stability of human immunoglobulin G protein with high sensitivity...

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Detalles Bibliográficos
Autores principales: Moggridge, Jason, Biggar, Kyle, Dawson, Neal, Storey, Kenneth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762059/
https://www.ncbi.nlm.nih.gov/pubmed/28602127
http://dx.doi.org/10.1177/1533034617714149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762059/
https://www.ncbi.nlm.nih.gov/pubmed/28602127
http://dx.doi.org/10.1177/1533034617714149

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