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Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics

Protein instability is a major obstacle in the production and delivery of monoclonal antibody–based therapies for cancer. This study presents real-time isothermal differential scanning fluorimetry as an emerging method to evaluate the stability of human immunoglobulin G protein with high sensitivity...

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Detalles Bibliográficos
Autores principales:	Moggridge, Jason, Biggar, Kyle, Dawson, Neal, Storey, Kenneth B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762059/ https://www.ncbi.nlm.nih.gov/pubmed/28602127 http://dx.doi.org/10.1177/1533034617714149

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