Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study()

A sensitive, selective and high-throughput liquid chromatography–tandem mass spectrometry (LC–ESI–MS/MS) method was developed and validated for the quantitation of tolvaptan in rabbit plasma. Sample clean-up involved liquid–liquid extraction (LLE) and chromatography was performed on Zorbax SB C(18)...

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Detalles Bibliográficos
Autores principales: Moola, Kumar S., Challa, Bala Sekhara Reddy, Bannoth, Chandrasekhar Kothapalli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762243/
https://www.ncbi.nlm.nih.gov/pubmed/29403951
http://dx.doi.org/10.1016/j.jpha.2014.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762243/
https://www.ncbi.nlm.nih.gov/pubmed/29403951
http://dx.doi.org/10.1016/j.jpha.2014.09.001

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