Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations()

Ezetimibe, which selectively inhibits cholesterol absorption across the intestinal wall and is used as an antihyperlipidemic agent, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of ezetimibe, an impurity was detected in th...

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Detalles Bibliográficos
Autores principales: Bellur Atici, Esen, Karlığa, Bekir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762248/
https://www.ncbi.nlm.nih.gov/pubmed/29403950
http://dx.doi.org/10.1016/j.jpha.2015.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762248/
https://www.ncbi.nlm.nih.gov/pubmed/29403950
http://dx.doi.org/10.1016/j.jpha.2015.04.002

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