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Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations()
Ezetimibe, which selectively inhibits cholesterol absorption across the intestinal wall and is used as an antihyperlipidemic agent, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of ezetimibe, an impurity was detected in th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Xi'an Jiaotong University
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762248/ https://www.ncbi.nlm.nih.gov/pubmed/29403950 http://dx.doi.org/10.1016/j.jpha.2015.04.002 |