Role and regulation of Yap in KrasG12D-induced lung cancer

The Hippo pathway and its downstream transcriptional co-activator Yap influence lung cancer, but the nature of the Yap contribution has been unclear. Using a genetically engineered mouse lung cancer model, we show that Yap deletion completely blocks KrasG12D and p53 loss-driven adenocarcinoma initia...

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Detalles Bibliográficos
Autores principales: Mao, Yaopan, Sun, Shuguo, Irvine, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762291/
https://www.ncbi.nlm.nih.gov/pubmed/29340023
http://dx.doi.org/10.18632/oncotarget.22865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762291/
https://www.ncbi.nlm.nih.gov/pubmed/29340023
http://dx.doi.org/10.18632/oncotarget.22865

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