YM155 exerts potent cytotoxic activity against quiescent (G(0)/G(1)) multiple myeloma and bortezomib resistant cells via inhibition of survivin and Mcl-1

YM155, a novel small molecule inhibitor of survivin, shows broad anticancer activity. Here, we have focused on the cytotoxic activity of YM155 against multiple myeloma (MM) including cytokinetically quiescent (G(0)/G(1)) cells and bortezomib resistant cells. YM155 strongly inhibited the growth of MM...

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Detalles Bibliográficos
Autores principales: Ookura, Miyuki, Fujii, Tatsuya, Yagi, Hideki, Ogawa, Takuya, Kishi, Shinji, Hosono, Naoko, Shigemi, Hiroko, Yamauchi, Takahiro, Ueda, Takanori, Yoshida, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762341/
https://www.ncbi.nlm.nih.gov/pubmed/29340073
http://dx.doi.org/10.18632/oncotarget.22871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762341/
https://www.ncbi.nlm.nih.gov/pubmed/29340073
http://dx.doi.org/10.18632/oncotarget.22871

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