Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax

Bcl-2 is often upregulated in cancers to neutralize the BH3-only protein Bim at the mitochondria. BH3 mimetics (e.g. ABT-199 (venetoclax)) kill cancer cells by targeting Bcl-2’s hydrophobic cleft and disrupting Bcl-2/Bim complexes. Some cancers with elevated Bcl-2 display poor responses towards BH3...

Descripción completa

Detalles Bibliográficos
Autores principales: Vervloessem, Tamara, Akl, Haidar, Tousseyn, Thomas, De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762350/
https://www.ncbi.nlm.nih.gov/pubmed/29340082
http://dx.doi.org/10.18632/oncotarget.22898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762350/
https://www.ncbi.nlm.nih.gov/pubmed/29340082
http://dx.doi.org/10.18632/oncotarget.22898

Ejemplares similares