Cargando…

Activation of AMPK by OSU53 protects spinal cord neurons from oxidative stress

The present study tested the potential effect of OSU53, a novel AMPK activator, against hydrogen peroxide (H2O2)-induced spinal cord neuron damages. Treatment with OSU53 attenuated H2O2-induced death and apoptosis of primary murine spinal cord neurons. OSU53 activated AMPK signaling, which is requir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Jun, Wu, Liang, Zhang, Yiming, Gu, Huijie, Huang, Zhongyue, Zhou, Kaifeng, Yin, Xiaofan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762526/ https://www.ncbi.nlm.nih.gov/pubmed/29348841 http://dx.doi.org/10.18632/oncotarget.22055

Ejemplares similares

OSU53 Rescues Human OB-6 Osteoblastic Cells from Dexamethasone through Activating AMPK Signaling
por: Xu, Dawei, et al.
Publicado: (2016)

MiR-409-3p Inhibits Cell Proliferation and Invasion of Osteosarcoma by Targeting Zinc-Finger E-Box-Binding Homeobox-1
por: Wu, Liang, et al.
Publicado: (2019)

Network and pathway-based analyses of genes associated with osteoporosis
por: Gu, Huijie, et al.
Publicado: (2020)

Expression Profile Analysis of Long Non-coding RNA in OVX Models-Derived BMSCs for Postmenopausal Osteoporosis by RNA Sequencing and Bioinformatics
por: Gu, Huijie, et al.
Publicado: (2021)

Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637/STAT3 Axis in Osteosarcoma
por: Huang, Zhongyue, et al.
Publicado: (2020)

Downregulation of microRNA-143 promotes osteogenic differentiation of human adipose-derived mesenchymal stem cells through the k-Ras/MEK/ERK signaling pathway
por: Zhang, Yiming, et al.
Publicado: (2020)

OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53
por: Omar, Hany A., et al.
Publicado: (2016)

Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
por: Zhao, Jianbo, et al.
Publicado: (2014)

Draft genome sequence of Lactobacillus helveticus OSU-BDGOAK2 and Lactobacillus kefiranofaciens OSU-BDGOA1, kefir grain isolates with potential antibacterial activity
por: González-Orozco, Brianda D., et al.
Publicado: (2023)

LINC00511 Promotes Osteosarcoma Tumorigenesis and Invasiveness through the miR-185-3p/E2F1 Axis
por: Xu, Jun, et al.
Publicado: (2020)

Comparison of 16 mm OSU‐Nag and COMS eye plaques
por: Zhang, Hualin, et al.
Publicado: (2012)

Astaxanthin protects spinal cord tissues from apoptosis after spinal cord injury in rats
por: Li, Shuang, et al.
Publicado: (2021)

Zinc Regulates Glucose Metabolism of the Spinal Cord and Neurons and Promotes Functional Recovery after Spinal Cord Injury through the AMPK Signaling Pathway
por: Hu, Hengshuo, et al.
Publicado: (2021)

Re-Assembly of the Genome of Francisella tularensis Subsp. holarctica OSU18
por: Puiu, Daniela, et al.
Publicado: (2008)

The effects of the dopamine stabilizer (−)-OSU6162 on aggressive and sexual behavior in rodents
por: Studer, E, et al.
Publicado: (2016)

Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence
por: Khemiri, Lotfi, et al.
Publicado: (2019)

Protective effect of zinc oxide nanoparticles on spinal cord injury
por: Liu, Jia, et al.
Publicado: (2022)

OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics
por: Van Belle, Kristien, et al.
Publicado: (2018)

1899. The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro
por: Chan, Jasper, et al.
Publicado: (2018)

Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
por: Cheng, Xiangyang, et al.
Publicado: (2018)

Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model
por: Zhao, Weiyi, et al.
Publicado: (2022)

Evaluation of cholera surveillance system in Osu Klottey District, Accra, Ghana (2011-2013)
por: Adjei, Eric Yirenkyi, et al.
Publicado: (2017)

OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
por: Ding, Leilei, et al.
Publicado: (2021)

Celecoxib Analogues for Cancer Treatment: An Update on OSU-03012 and 2,5-Dimethyl-Celecoxib
por: Sobolewski, Cyril, et al.
Publicado: (2021)

Metformin Protects against Spinal Cord Injury and Cell Pyroptosis via AMPK/NLRP3 Inflammasome Pathway
por: Yuan, Yajiang, et al.
Publicado: (2022)

Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway
por: Chen, Guangnan, et al.
Publicado: (2020)

Diallyl trisulfide improves spinal cord ischemia–reperfusion injury damage by activating AMPK to stabilize mitochondrial function
por: Sun, Yang, et al.
Publicado: (2023)

MicroRNA-299a-5p Protects against Spinal Cord Injury through Activating AMPK Pathway
por: Zhang, Zong-Ze, et al.
Publicado: (2022)

Aurora kinase A is a possible target of OSU-03012 to destabilize MYC family proteins
por: SILVA, ANDRES, et al.
Publicado: (2014)

Open‐label study with the monoamine stabilizer (‐)‐OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome
por: Haghighi, Sara, et al.
Publicado: (2021)

Identification of Putative β-Galactosidase Genes in the Genome of Lactobacillus helveticus OSU-PECh-4A
por: García-Cano, Israel, et al.
Publicado: (2022)

RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway in Mice
por: Dao, Wenxin, et al.
Publicado: (2022)

Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis
por: Wang, Huichao, et al.
Publicado: (2020)

The protective effect of microRNA-21 in neurons after spinal cord injury
por: Zhang, Tao, et al.
Publicado: (2018)

Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury
por: Myatich, Ali, et al.
Publicado: (2022)

Circular RNA circFAT1(e2) Promotes Osteosarcoma Progression and Metastasis by Sponging miR-181b and Regulating HK2 Expression
por: Gu, Huijie, et al.
Publicado: (2020)

Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy
por: Gu, Changjiang, et al.
Publicado: (2020)

Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
por: Gu, Changjiang, et al.
Publicado: (2023)

The monoamine stabilizer (−)‐OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats
por: Fredriksson, Ida, et al.
Publicado: (2018)

Draft Genome Sequence of Lactobacillus rhamnosus OSU-PECh-69, a Cheese Isolate with Antibacterial Activity
por: García-Cano, Israel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uhsn0n0l0b0nusdair4v4cro08