3D-cultivation of NSCLC cell lines induce gene expression alterations of key cancer-associated pathways and mimic in-vivo conditions

This work evaluated gene expression differences between a hanging-drop 3D NSCLC model and 2D cell cultures and their in-vivo relevance by comparison to patient-derived data from The Cancer Genome Atlas. Gene expression of 2D and 3D cultures for Colo699 and A549 were assessed using Affymetrix HuGene...

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Detalles Bibliográficos
Autores principales: Gamerith, Gabriele, Rainer, Johannes, Huber, Julia M., Hackl, Hubert, Trajanoski, Zlatko, Koeck, Stefan, Lorenz, Edith, Kern, Johann, Kofler, Reinhard, Kelm, Jens M., Zwierzina, Heinz, Amann, Arno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762538/
https://www.ncbi.nlm.nih.gov/pubmed/29348853
http://dx.doi.org/10.18632/oncotarget.22636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762538/
https://www.ncbi.nlm.nih.gov/pubmed/29348853
http://dx.doi.org/10.18632/oncotarget.22636

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