Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism

Diabetes and vascular calcification are intrinsically linked. We previously reported that advanced glycation end products (AGEs) accelerate calcium deposition in vascular smooth muscle cells (VSMCs) via excessive oxidative stress. However, the underlying mechanism remains poorly understood. Pyruvate...

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Detalles Bibliográficos
Autores principales: Ma, Wen-Qi, Han, Xi-Qiong, Wang, Ying, Wang, Xin, Zhu, Yi, Liu, Nai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762555/
https://www.ncbi.nlm.nih.gov/pubmed/29348870
http://dx.doi.org/10.18632/oncotarget.22835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762555/
https://www.ncbi.nlm.nih.gov/pubmed/29348870
http://dx.doi.org/10.18632/oncotarget.22835

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