8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells

8u, an acridine derivative, has been proved effective anti-hepatocarcinoma effect, while the underlying mechanism remains unclear. Here, metabolomics and proteomics approaches were applied to study its anti-cancer mechanism and explore its effect on HepG2 cells’ invasion and metastasis abilities. Th...

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Detalles Bibliográficos
Autores principales: Wang, Ning, Chen, Shaopeng, Zhang, Bin, Li, Shangfu, Jin, Feng, Gao, Dan, Liu, Hongxia, Jiang, Yuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762664/
https://www.ncbi.nlm.nih.gov/pubmed/29321577
http://dx.doi.org/10.1038/s41598-017-18701-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762664/
https://www.ncbi.nlm.nih.gov/pubmed/29321577
http://dx.doi.org/10.1038/s41598-017-18701-3

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