Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

Neuroinflammation is involved in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a mitochondrial kinase linked to recessive familial PD – leads to glia type-specific abnormalities of innate immunity. PINK1 loss enhances LPS/IFN-γ stimul...

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Detalles Bibliográficos
Autores principales: Sun, Liuke, Shen, Ruifang, Agnihotri, Sandeep K., Chen, Yun, Huang, Zhiwei, Büeler, Hansruedi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762685/
https://www.ncbi.nlm.nih.gov/pubmed/29321620
http://dx.doi.org/10.1038/s41598-017-18786-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762685/
https://www.ncbi.nlm.nih.gov/pubmed/29321620
http://dx.doi.org/10.1038/s41598-017-18786-w

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