N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-β (Aβ) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same Aβ sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and Aβ of thes...

Descripción completa

Detalles Bibliográficos
Autores principales: Kugaevskaya, Elena V., Veselovsky, Alexander V., Indeykina, Maria I., Solovyeva, Nina I., Zharkova, Maria S., Popov, Igor A., Nikolaev, Eugene N., Mantsyzov, Alexey B., Makarov, Alexander A., Kozin, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762728/
https://www.ncbi.nlm.nih.gov/pubmed/29321566
http://dx.doi.org/10.1038/s41598-017-18567-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762728/
https://www.ncbi.nlm.nih.gov/pubmed/29321566
http://dx.doi.org/10.1038/s41598-017-18567-5

Ejemplares similares