Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity

Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. We provide biochemical and developmental evidence identifying acetaldehyde as responsible for this inhibition. In the...

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Detalles Bibliográficos
Autores principales: Shabtai, Yehuda, Bendelac, Liat, Jubran, Halim, Hirschberg, Joseph, Fainsod, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762763/
https://www.ncbi.nlm.nih.gov/pubmed/29321611
http://dx.doi.org/10.1038/s41598-017-18719-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762763/
https://www.ncbi.nlm.nih.gov/pubmed/29321611
http://dx.doi.org/10.1038/s41598-017-18719-7

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