Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity

Epertinib (S-222611) is a potent, reversible, and selective tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), human EGFR2 (HER2), and human EGFR4. We developed experimental brain metastasis models by intraventricular injection (intraventricular injection mouse model; IVM) of HER2...

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Detalles Bibliográficos
Autores principales: Tanaka, Yukari, Hirata, Michinari, Shinonome, Satomi, Torii, Mikinori, Nezasa, Ken-ichi, Tanaka, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762859/
https://www.ncbi.nlm.nih.gov/pubmed/29321587
http://dx.doi.org/10.1038/s41598-017-18702-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762859/
https://www.ncbi.nlm.nih.gov/pubmed/29321587
http://dx.doi.org/10.1038/s41598-017-18702-2

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