A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells

Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized a novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh(3))(2)(bipy)]PF(6) (PPh(3) = triphen...

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Detalles Bibliográficos
Autores principales: Silva, Valdenizia Rodrigues, Corrêa, Rodrigo S., Santos, Luciano de Souza, Soares, Milena Botelho Pereira, Batista, Alzir Azevedo, Bezerra, Daniel Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762908/
https://www.ncbi.nlm.nih.gov/pubmed/29321581
http://dx.doi.org/10.1038/s41598-017-18639-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762908/
https://www.ncbi.nlm.nih.gov/pubmed/29321581
http://dx.doi.org/10.1038/s41598-017-18639-6

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