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Probing the molecular basis of hERG drug block with unnatural amino acids
Repolarization of the cardiac action potential is primarily mediated by two voltage-dependent potassium currents: I (Kr) and I (Ks). The voltage-gated potassium channel that gives rise to I (Kr), K(v)11.1 (hERG), is uniquely susceptible to high-affinity block by a wide range of drug classes. Pore re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762913/ https://www.ncbi.nlm.nih.gov/pubmed/29321549 http://dx.doi.org/10.1038/s41598-017-18448-x |