Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. At the early stages of AD development, the soluble β-amyloid (Aβ) induces synaptic dysfunction, perturbs the excitation/inhibition balance of neural circuitries, and in turn alters the normal neural network activity leadin...

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Detalles Bibliográficos
Autores principales: Ren, Si-Qiang, Yao, Wen, Yan, Jing-Zhi, Jin, Chunhui, Yin, Jia-Jun, Yuan, Jianmin, Yu, Shui, Cheng, Zaohuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762926/
https://www.ncbi.nlm.nih.gov/pubmed/29321592
http://dx.doi.org/10.1038/s41598-017-18729-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762926/
https://www.ncbi.nlm.nih.gov/pubmed/29321592
http://dx.doi.org/10.1038/s41598-017-18729-5

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