An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53

R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain....

Descripción completa

Detalles Bibliográficos
Autores principales: Malami, Ibrahim, Muhammad, Aliyu, Etti, Imaobong C., Waziri, Peter M., Alhassan, Alhassan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763090/
https://www.ncbi.nlm.nih.gov/pubmed/29333130
http://dx.doi.org/10.17179/excli2017-299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763090/
https://www.ncbi.nlm.nih.gov/pubmed/29333130
http://dx.doi.org/10.17179/excli2017-299

Ejemplares similares