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Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
Different regions in the mammalian adult brain contain immature precursors, reinforcing the concept that brain cancers, such as glioblastoma multiforme (GBM), may originate from cells endowed with stem-like properties. Alterations of the tumour suppressor gene PTEN are very common in primary GBMs. V...
Autores principales: | Paglia, Simona, Sollazzo, Manuela, Di Giacomo, Simone, de Biase, Dario, Pession, Annalisa, Grifoni, Daniela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763105/ https://www.ncbi.nlm.nih.gov/pubmed/29445734 http://dx.doi.org/10.1155/2017/2690187 |
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