Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries

Human autonomous V(H)/V(L) single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens. Most commonly, human sdAbs have been isolated from in vitro display libraries constructed via synthetic randomiz...

Descripción completa

Detalles Bibliográficos
Autores principales: Henry, Kevin A., Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Schrag, Joseph D., Hussack, Greg, MacKenzie, C. Roger, Tanha, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763143/
https://www.ncbi.nlm.nih.gov/pubmed/29375542
http://dx.doi.org/10.3389/fimmu.2017.01759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763143/
https://www.ncbi.nlm.nih.gov/pubmed/29375542
http://dx.doi.org/10.3389/fimmu.2017.01759

Ejemplares similares