A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier

The chemical synthesis and biological activity of novel functionalized imidazoquinoline derivatives (ImQ) to generate Toll‐like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirmed in zebrafish larvae. After covalent ligation to fully biod...

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Detalles Bibliográficos
Autores principales: Aichhorn, Stefan, Linhardt, Anne, Halfmann, Angela, Nadlinger, Markus, Kirchberger, Stefanie, Stadler, Manuela, Dillinger, Barbara, Distel, Martin, Dohnal, Alexander, Teasdale, Ian, Schöfberger, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763314/
https://www.ncbi.nlm.nih.gov/pubmed/28758266
http://dx.doi.org/10.1002/chem.201702942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763314/
https://www.ncbi.nlm.nih.gov/pubmed/28758266
http://dx.doi.org/10.1002/chem.201702942

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