An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

BACKGROUND: RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not been fully explored. Recent work on cancer genome databases has revealed a reoccu...

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Detalles Bibliográficos
Autores principales: Heard, Jeffrey J., Phung, Ivy, Potes, Mark I., Tamanoi, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763582/
https://www.ncbi.nlm.nih.gov/pubmed/29320991
http://dx.doi.org/10.1186/s12885-017-3938-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763582/
https://www.ncbi.nlm.nih.gov/pubmed/29320991
http://dx.doi.org/10.1186/s12885-017-3938-5

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