RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

BACKGROUND: Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Ren, Dong, Li, Su, Ma, Wenli, Hu, Shaoyan, Jin, Yan, Xiao, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763756/
https://www.ncbi.nlm.nih.gov/pubmed/29321004
http://dx.doi.org/10.1186/s12885-017-3908-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763756/
https://www.ncbi.nlm.nih.gov/pubmed/29321004
http://dx.doi.org/10.1186/s12885-017-3908-y

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