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RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation
BACKGROUND: Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763756/ https://www.ncbi.nlm.nih.gov/pubmed/29321004 http://dx.doi.org/10.1186/s12885-017-3908-y |