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Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease

In the last few years, accumulating evidence has shown the existence of an important cross-talk between adenosine A(2A) receptors (A(2A)Rs) and brain-derived neurotrophic factor (BDNF). Not only are A(2A)Rs involved in the mechanism of transactivation of BDNF receptor TrkB, they also modulate the ef...

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Autores principales: Tebano, Maria Teresa, Martire, Alberto, Chiodi, Valentina, Ferrante, Antonella, Popoli, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763899/
https://www.ncbi.nlm.nih.gov/pubmed/20842321
http://dx.doi.org/10.1100/tsw.2010.164
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author Tebano, Maria Teresa
Martire, Alberto
Chiodi, Valentina
Ferrante, Antonella
Popoli, Patrizia
author_facet Tebano, Maria Teresa
Martire, Alberto
Chiodi, Valentina
Ferrante, Antonella
Popoli, Patrizia
author_sort Tebano, Maria Teresa
collection PubMed
description In the last few years, accumulating evidence has shown the existence of an important cross-talk between adenosine A(2A) receptors (A(2A)Rs) and brain-derived neurotrophic factor (BDNF). Not only are A(2A)Rs involved in the mechanism of transactivation of BDNF receptor TrkB, they also modulate the effect of BDNF on synaptic transmission, playing a facilitatory and permissive role. The cAMP-PKA pathway, the main transduction system operated by A(2A)Rs, is involved in such effects. Furthermore, a basal tonus of A(2A)Rs is required to allow the regulation of BDNF physiological levels in the brain, as demonstrated by the reduced protein levels measured in A(2A)Rs KO mice. The crucial role of adenosine A(2A)Rs in the maintenance of synaptic functions and BDNF levels will be reviewed here and discussed in the light of possible implications for Huntington's disease therapy, in which a joint impairment of BDNF and A(2A)Rs seems to play a pathogenetic role.
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spelling pubmed-57638992018-06-03 Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease Tebano, Maria Teresa Martire, Alberto Chiodi, Valentina Ferrante, Antonella Popoli, Patrizia ScientificWorldJournal Review Article In the last few years, accumulating evidence has shown the existence of an important cross-talk between adenosine A(2A) receptors (A(2A)Rs) and brain-derived neurotrophic factor (BDNF). Not only are A(2A)Rs involved in the mechanism of transactivation of BDNF receptor TrkB, they also modulate the effect of BDNF on synaptic transmission, playing a facilitatory and permissive role. The cAMP-PKA pathway, the main transduction system operated by A(2A)Rs, is involved in such effects. Furthermore, a basal tonus of A(2A)Rs is required to allow the regulation of BDNF physiological levels in the brain, as demonstrated by the reduced protein levels measured in A(2A)Rs KO mice. The crucial role of adenosine A(2A)Rs in the maintenance of synaptic functions and BDNF levels will be reviewed here and discussed in the light of possible implications for Huntington's disease therapy, in which a joint impairment of BDNF and A(2A)Rs seems to play a pathogenetic role. TheScientificWorldJOURNAL 2010-09-01 /pmc/articles/PMC5763899/ /pubmed/20842321 http://dx.doi.org/10.1100/tsw.2010.164 Text en Copyright © 2010 Maria Teresa Tebano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tebano, Maria Teresa
Martire, Alberto
Chiodi, Valentina
Ferrante, Antonella
Popoli, Patrizia
Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title_full Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title_fullStr Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title_full_unstemmed Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title_short Role of Adenosine A(2A) Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease
title_sort role of adenosine a(2a) receptors in modulating synaptic functions and brain levels of bdnf: a possible key mechanism in the pathophysiology of huntington's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763899/
https://www.ncbi.nlm.nih.gov/pubmed/20842321
http://dx.doi.org/10.1100/tsw.2010.164
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