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Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival

B-cell lymphoma 2 protein (BCL-2) is one of the more widely investigated anti-apoptotic protein in mammals, and its levels are critical for protecting from programmed cell death. We report here that the cellular content of BCL-2 is regulated at post-translational level along the autophagy/lysosome p...

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Autores principales: Lossi, Laura, Gambino, Graziana, Salio, Chiara, Merighi, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763967/
https://www.ncbi.nlm.nih.gov/pubmed/20495771
http://dx.doi.org/10.1100/tsw.2010.82
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author Lossi, Laura
Gambino, Graziana
Salio, Chiara
Merighi, Adalberto
author_facet Lossi, Laura
Gambino, Graziana
Salio, Chiara
Merighi, Adalberto
author_sort Lossi, Laura
collection PubMed
description B-cell lymphoma 2 protein (BCL-2) is one of the more widely investigated anti-apoptotic protein in mammals, and its levels are critical for protecting from programmed cell death. We report here that the cellular content of BCL-2 is regulated at post-translational level along the autophagy/lysosome pathways in organotypic cultures of post-natal mouse cerebellar cortex. Specifically this mechanism appears to be effective in the cerebellar granule cells (CGCs) that are known to undergo massive programmed cell death (apoptosis) during post-natal maturation. By the use of specific agonists/antagonist of calcium channels at the endoplasmic reticulum it was possible to understand the pivotal role of calcium release from intracellular stores in CGC neuroprotection. The more general significance of these findings is supported by a very recent study Niemann-Pick transgenic mice.
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spelling pubmed-57639672018-06-03 Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival Lossi, Laura Gambino, Graziana Salio, Chiara Merighi, Adalberto ScientificWorldJournal Directions in Science B-cell lymphoma 2 protein (BCL-2) is one of the more widely investigated anti-apoptotic protein in mammals, and its levels are critical for protecting from programmed cell death. We report here that the cellular content of BCL-2 is regulated at post-translational level along the autophagy/lysosome pathways in organotypic cultures of post-natal mouse cerebellar cortex. Specifically this mechanism appears to be effective in the cerebellar granule cells (CGCs) that are known to undergo massive programmed cell death (apoptosis) during post-natal maturation. By the use of specific agonists/antagonist of calcium channels at the endoplasmic reticulum it was possible to understand the pivotal role of calcium release from intracellular stores in CGC neuroprotection. The more general significance of these findings is supported by a very recent study Niemann-Pick transgenic mice. TheScientificWorldJOURNAL 2010-05-18 /pmc/articles/PMC5763967/ /pubmed/20495771 http://dx.doi.org/10.1100/tsw.2010.82 Text en Copyright © 2010 Laura Lossi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Directions in Science
Lossi, Laura
Gambino, Graziana
Salio, Chiara
Merighi, Adalberto
Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title_full Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title_fullStr Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title_full_unstemmed Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title_short Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
title_sort autophagy regulates the post-translational cleavage of bcl-2 and promotes neuronal survival
topic Directions in Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763967/
https://www.ncbi.nlm.nih.gov/pubmed/20495771
http://dx.doi.org/10.1100/tsw.2010.82
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