Indoleamine 2,3-Dioxygenase Activity Increases NAD+ Production in IFN-γ–Stimulated Human Primary Mononuclear Cells

IFN-γ activation of mononuclear phagocytes significantly increases indoleamine 2,3-dioxygenase (IDO) and flux through the kynurenine pathway (KP). However, the effect of IDO on NAD+ synthesis, the end product of KP metabolism, is unknown. To investigate this, primary human peripheral blood mononucle...

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Detalles Bibliográficos
Autor principal: Grant, Ross S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764136/
https://www.ncbi.nlm.nih.gov/pubmed/29343967
http://dx.doi.org/10.1177/1178646917751636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764136/
https://www.ncbi.nlm.nih.gov/pubmed/29343967
http://dx.doi.org/10.1177/1178646917751636

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