POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions

Robust DNA double strand break (DSB) repair and stabilized telomeres help maintain genome integrity, preventing the onset of aging or tumorigenesis. POT1 is one of the six factors in the shelterin complex, which protects telomeres from being recognized as DNA damages. TRF1 and TRF2, two other shelte...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Tan, Rong, Ren, Qian, Gao, Boya, Sheng, Zhejin, Zhang, Juanlian, Zheng, Xiaoqing, Jiang, Ying, Lan, Li, Mao, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764391/
https://www.ncbi.nlm.nih.gov/pubmed/29227966
http://dx.doi.org/10.18632/aging.101339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764391/
https://www.ncbi.nlm.nih.gov/pubmed/29227966
http://dx.doi.org/10.18632/aging.101339

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