Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side effects on cell viability. Using this approach, w...

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Detalles Bibliográficos
Autores principales: Ozsvari, Bela, Bonuccelli, Gloria, Sanchez-Alvarez, Rosa, Foster, Richard, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764395/
https://www.ncbi.nlm.nih.gov/pubmed/29253841
http://dx.doi.org/10.18632/aging.101351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764395/
https://www.ncbi.nlm.nih.gov/pubmed/29253841
http://dx.doi.org/10.18632/aging.101351

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