Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

The microenvironment of prostate cancer often includes abundant tumor-associated macrophages (TAMs), with their acquisition of an M2 phenotype correlating with local aggressiveness and metastasis. Tumor-derived M-CSF contributes to TAM M2 polarization, and M-CSF receptor inhibition slows prostate ca...

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Detalles Bibliográficos
Autores principales: Barakat, David J., Suresh, Rahul, Barberi, Theresa, Pienta, Kenneth J., Simons, Brian W., Friedman, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764416/
https://www.ncbi.nlm.nih.gov/pubmed/29324844
http://dx.doi.org/10.1371/journal.pone.0191188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764416/
https://www.ncbi.nlm.nih.gov/pubmed/29324844
http://dx.doi.org/10.1371/journal.pone.0191188

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