Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis

Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by binding calmodulin (CaM) to produce supraphysiological levels of cAMP, inducing cell death. Using a combinat...

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Detalles Bibliográficos
Autores principales: O’Brien, Darragh P., Durand, Dominique, Voegele, Alexis, Hourdel, Véronique, Davi, Marilyne, Chamot-Rooke, Julia, Vachette, Patrice, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764468/
https://www.ncbi.nlm.nih.gov/pubmed/29287065
http://dx.doi.org/10.1371/journal.pbio.2004486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764468/
https://www.ncbi.nlm.nih.gov/pubmed/29287065
http://dx.doi.org/10.1371/journal.pbio.2004486

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