The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin proteins and hydrolytic enzymes. The glycosphingolipid galactocerebroside...

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Detalles Bibliográficos
Autores principales: Hill, Chris H., Cook, Georgia M., Spratley, Samantha J., Fawke, Stuart, Graham, Stephen C., Deane, Janet E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764952/
https://www.ncbi.nlm.nih.gov/pubmed/29323104
http://dx.doi.org/10.1038/s41467-017-02361-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764952/
https://www.ncbi.nlm.nih.gov/pubmed/29323104
http://dx.doi.org/10.1038/s41467-017-02361-y

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