Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression

While human Tregs hold immense promise for immunotherapy, their biologic variability poses challenges for clinical use. Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tregs. Unlike highly suppressive but plastic memory...

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Detalles Bibliográficos
Autores principales: Donnelly, Conor, Dykstra, Brad, Mondal, Nandini, Huang, Junning, Kaskow, Belinda J., Griffin, Russell, Sackstein, Robert, Baecher-Allan, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765004/
https://www.ncbi.nlm.nih.gov/pubmed/29323143
http://dx.doi.org/10.1038/s41598-017-17981-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765004/
https://www.ncbi.nlm.nih.gov/pubmed/29323143
http://dx.doi.org/10.1038/s41598-017-17981-z

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