Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes

In this study, the biotransformation in the plasma, urine and feces of rats following oral administration of protopine (PRO) and allocryptopine (ALL)were explored using HPLC-QqTOF MS. An HPLC-MS/MS method for the determination of tissues was developed and applied to the tissue distribution study in...

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Detalles Bibliográficos
Autores principales: Huang, Ya-Jun, Cheng, Pi, Zhang, Zhuo-Yi, Tian, Shi-Jie, Sun, Zhi-Liang, Zeng, Jian-Guo, Liu, Zhao-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765031/
https://www.ncbi.nlm.nih.gov/pubmed/29323165
http://dx.doi.org/10.1038/s41598-017-18816-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765031/
https://www.ncbi.nlm.nih.gov/pubmed/29323165
http://dx.doi.org/10.1038/s41598-017-18816-7

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