Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not been reported. Herein, metformin induced pAMPK activation and pS6 suppression in metformin-sensitive (HT29) cells, but not in metformin-...

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Detalles Bibliográficos
Autores principales: Kim, Jae Hyun, Lee, Kyoung Jin, Seo, Yoojeong, Kwon, Ji-Hee, Yoon, Jae Pil, Kang, Jo Yeon, Lee, Hyun Jung, Park, Soo Jung, Hong, Sung Pil, Cheon, Jae Hee, Kim, Won Ho, Il Kim, Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765079/
https://www.ncbi.nlm.nih.gov/pubmed/29323154
http://dx.doi.org/10.1038/s41598-017-18762-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765079/
https://www.ncbi.nlm.nih.gov/pubmed/29323154
http://dx.doi.org/10.1038/s41598-017-18762-4

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