Cargando…

Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not been reported. Herein, metformin induced pAMPK activation and pS6 suppression in metformin-sensitive (HT29) cells, but not in metformin-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jae Hyun, Lee, Kyoung Jin, Seo, Yoojeong, Kwon, Ji-Hee, Yoon, Jae Pil, Kang, Jo Yeon, Lee, Hyun Jung, Park, Soo Jung, Hong, Sung Pil, Cheon, Jae Hee, Kim, Won Ho, Il Kim, Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765079/ https://www.ncbi.nlm.nih.gov/pubmed/29323154 http://dx.doi.org/10.1038/s41598-017-18762-4

Ejemplares similares

Publisher Correction: Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism
por: Kim, Jae Hyun, et al.
Publicado: (2018)

Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer
por: Seo, Yoojeong, et al.
Publicado: (2020)

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer
por: Kang, Joyeon, et al.
Publicado: (2022)

Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients
por: Park, Jung Won, et al.
Publicado: (2017)

Comparison of Colonoscopy Surveillance Outcomes Between Young and Older Colorectal Cancer Patients
por: Kim, Sung Bae, et al.
Publicado: (2017)

The Learning Curve for Colorectal Stent Insertion for the Treatment of Malignant Colorectal Obstruction
por: Lee, Ji Hoon, et al.
Publicado: (2012)

The relationship between diverticulosis and colorectal neoplasia: A meta-analysis
por: Lee, Hyun Jung, et al.
Publicado: (2019)

Clinical Efficacy of Beclomethasone Dipropionate in Korean Patients with Ulcerative Colitis
por: Lee, Yoon Jee, et al.
Publicado: (2017)

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer
por: Kang, Hee Eun, et al.
Publicado: (2021)

MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers
por: Seo, Yoojeong, et al.
Publicado: (2022)

Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
por: Lee, Hyun Jung, et al.
Publicado: (2016)

Long-Term Outcome and Surveillance Colonoscopy after Successful Endoscopic Treatment of Large Sessile Colorectal Polyps
por: Kim, Bun, et al.
Publicado: (2016)

Efficacy of Adalimumab in Korean Patients with Crohn’s Disease
por: Sohn, Il Woong, et al.
Publicado: (2016)

Clinical Efficacy of Endoscopic Treatment for Benign Colorectal Stricture: Balloon Dilatation versus Stenting
por: Park, Chan Hyuk, et al.
Publicado: (2015)

The risk of lymph node metastasis makes it unsafe to expand the conventional indications for endoscopic treatment of T1 colorectal cancer: A retrospective study of 428 patients
por: Kim, Bun, et al.
Publicado: (2016)

Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease
por: Jang, Hui Won, et al.
Publicado: (2016)

Overlooked Management and Risk Factors for Anemia in Patients with Intestinal Behçet’s Disease in Actual Clinical Practice
por: Kim, Bun, et al.
Publicado: (2015)

Association of Family History With Cancer Recurrence, Survival, and the Incidence of Colorectal Adenoma in Patients With Colorectal Cancer
por: Park, Yehyun, et al.
Publicado: (2019)

Does a Pre-Training Program Influence Colonoscopy Proficiency during Fellowship?
por: Kim, Duk Hwan, et al.
Publicado: (2016)

Child-Pugh Score Is an Independent Risk Factor for Immediate Bleeding after Colonoscopic Polypectomy in Liver Cirrhosis
por: Lee, Sangheun, et al.
Publicado: (2014)

Correlation between Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Endoscopic Activity in Intestinal Behçet's Disease
por: Lee, Hyun Jung, et al.
Publicado: (2014)

Impact of Visceral Fat on Survival and Metastasis of Stage III Colorectal Cancer
por: Park, Jung Won, et al.
Publicado: (2022)

Risk Factors for Recurrent High-Risk Polyps after the Removal of High-Risk Polyps at Initial Colonoscopy
por: Jang, Hui Won, et al.
Publicado: (2015)

Radiation Exposure from Abdominal Imaging Studies in Patients with Intestinal Behçet Disease
por: Jung, Yoon Suk, et al.
Publicado: (2014)

Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence
por: Park, Jihye, et al.
Publicado: (2018)

Usefulness of Measuring Serum Procalcitonin Levels in Patients with Inflammatory Bowel Disease
por: Chung, Sook Hee, et al.
Publicado: (2016)

Factors Predictive of High-Risk Adenomas at the Third Colonoscopy after Initial Adenoma Removal
por: Chung, Sook Hee, et al.
Publicado: (2013)

Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study
por: Kim, Eun Hye, et al.
Publicado: (2015)

mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer
por: Chang, Ji Young, et al.
Publicado: (2020)

Specific Movement of Esophagus During Transient Lower Esophageal Sphincter Relaxation in Gastroesophageal Reflux Disease
por: Kim, Hoon Il, et al.
Publicado: (2013)

Efficacy of early immunomodulator therapy on the outcomes of Crohn’s disease
por: Kwak, Min Seob, et al.
Publicado: (2014)

Vaccination and Complementary and Alternative Medicine in Patients with Inflammatory Bowel Disease
por: Kim, Sung Bae, et al.
Publicado: (2014)

Clinical characteristics and risk factors related to polyposis recurrence and advanced neoplasm development among patients with non-hereditary colorectal polyposis
por: Jang, Jihun, et al.
Publicado: (2023)

Glutamine Synthetase as a Therapeutic Target for Cancer Treatment
por: Kim, Go Woon, et al.
Publicado: (2021)

Inflammatory Bowel Disease Cohort Studies in Korea: Present and Future
por: Lee, Jung Won, et al.
Publicado: (2015)

Patient-specific Guides Using 3-dimensional Reconstruction Provide Accuracy and Reproducibility in Reverse Total Shoulder Arthroplasty
por: Yoon, Jong Pil, et al.
Publicado: (2019)

Takayasu arteritis and antiphospholipid antibody syndrome in an elderly woman
por: Lee, Hee-Jeong, et al.
Publicado: (2015)

The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease
por: Lee, Hye Won, et al.
Publicado: (2016)

Long-term follow-up may be needed for pancreaticobiliary reflux in healthy adults
por: Yun, Sung-Pil, et al.
Publicado: (2013)

Effect of abutment neck taper and cement types on the amount of remnant cement in cement-retained implant restorations: an in vitro study
por: Park, Yeon-Hee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fav3giiqu8p561idonnccaa65e