Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Dengue virus (DENV) utilizes the endoplasmic reticulum (ER) for replication and assembling. Accumulation of unfolded proteins in the ER lumen leads to ER stress and unfolded protein response (UPR). Three branches of UPRs temporally modulated DENV infection. Moreover, ER stress can also induce autoph...

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Detalles Bibliográficos
Autores principales: Lee, Ying-Ray, Kuo, Szu-Han, Lin, Ching-Yen, Fu, Po-Jung, Lin, Yee-Shin, Yeh, Trai-Ming, Liu, Hsiao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765116/
https://www.ncbi.nlm.nih.gov/pubmed/29323257
http://dx.doi.org/10.1038/s41598-017-18909-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765116/
https://www.ncbi.nlm.nih.gov/pubmed/29323257
http://dx.doi.org/10.1038/s41598-017-18909-3

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