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In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis
The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc (−/−) and Optc (+/+) mice. Ten weeks post-surgery, cartilage was processed...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765138/ https://www.ncbi.nlm.nih.gov/pubmed/29323130 http://dx.doi.org/10.1038/s41598-017-18047-w |