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In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc (−/−) and Optc (+/+) mice. Ten weeks post-surgery, cartilage was processed...

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Detalles Bibliográficos
Autores principales:	Farrán, Aina, Valverde-Franco, Gladys, Tío, Laura, Lussier, Bertrand, Fahmi, Hassan, Pelletier, Jean-Pierre, Bishop, Paul N., Monfort, Jordi, Martel-Pelletier, Johanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765138/ https://www.ncbi.nlm.nih.gov/pubmed/29323130 http://dx.doi.org/10.1038/s41598-017-18047-w

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