Molecular determinants of Ca(2+) sensitivity at the intersubunit interface of the BK channel gating ring

The large-conductance calcium-activated K(+) (BK) channel contains two intracellular tandem Ca(2+)-sensing RCK domains (RCK1 and RCK2), which tetramerize into a Ca(2+) gating ring that regulates channel opening by conformational expansion in response to Ca(2+) binding. Interestingly, the gating ring...

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Detalles Bibliográficos
Autores principales: Li, Qin, Li, Yingxin, Wei, Hua, Pan, Hao-Min, Vouga, Alexandre G., Rothberg, Brad S., Wu, Yunkun, Yan, Jiusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765161/
https://www.ncbi.nlm.nih.gov/pubmed/29323236
http://dx.doi.org/10.1038/s41598-017-19029-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765161/
https://www.ncbi.nlm.nih.gov/pubmed/29323236
http://dx.doi.org/10.1038/s41598-017-19029-8

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