Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study

The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is developing and validating a mechanistic‐based assessment of the proarrhythmic risk of drugs. CiPA proposes to assess a drug's effect on multiple ion channels and integrate the effects in a computer model of the human cardiomyoc...

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Detalles Bibliográficos
Autores principales: Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Mason, Jay, Sager, Philip, Patel, Vikram, Matta, Murali K., Li, Zhihua, Liu, Jiang, Garnett, Christine, Stockbridge, Norman, Zineh, Issam, Strauss, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
State of the Art
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765372/
https://www.ncbi.nlm.nih.gov/pubmed/28986934
http://dx.doi.org/10.1002/cpt.896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765372/
https://www.ncbi.nlm.nih.gov/pubmed/28986934
http://dx.doi.org/10.1002/cpt.896

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