Protein kinase- and lipase inhibitors of inositide metabolism deplete IP(7) indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP(7), is at a high level...

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Detalles Bibliográficos
Autores principales: Rajasekaran, Subu Surendran, Illies, Christopher, Shears, Stephen B., Wang, Huanchen, Ayala, Thais S., Martins, Joilson O., Daré, Elisabetta, Berggren, Per-Olof, Barker, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765549/
https://www.ncbi.nlm.nih.gov/pubmed/29042286
http://dx.doi.org/10.1016/j.cellsig.2017.10.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765549/
https://www.ncbi.nlm.nih.gov/pubmed/29042286
http://dx.doi.org/10.1016/j.cellsig.2017.10.008

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