Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells

BACKGROUND: Hypermethylation is observed in the promoter regions of suppressor genes in the tumor cancer cells. Reactivation of these genes by demethylation of their promoters is a prospective strategy of the anticancer therapy. Previous experiments have shown that symmetric dimeric bisbenzimidazole...

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Detalles Bibliográficos
Autores principales: Kostyuk, Svetlana V., Kvasha, Margarita A., Khrabrova, Daria A., Kirsanova, Olga V., Ershova, Elizaveta S., Malinovskaya, Elena M., Veiko, Natalia N., Ivanov, Alexander A., Koval, Vasiliy S., Zhuze, Alexei L., Tashlitsky, Vadim H., Umriukhin, Pavel E., Kutsev, Sergey I., Gromova, Elizaveta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766121/
https://www.ncbi.nlm.nih.gov/pubmed/29329300
http://dx.doi.org/10.1371/journal.pone.0189826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766121/
https://www.ncbi.nlm.nih.gov/pubmed/29329300
http://dx.doi.org/10.1371/journal.pone.0189826

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