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Combining asymmetric (13)C-labeling and isotopic filter/edit NOESY: a novel strategy for rapid and logical RNA resonance assignment

Although ∼98% of the human genomic output is transcribed as non-protein coding RNA, <2% of the protein data bank structures comprise RNA. This huge structural disparity stems from combined difficulties of crystallizing RNA for X-ray crystallography along with extensive chemical shift overlap and...

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Detalles Bibliográficos
Autores principales: LeBlanc, Regan M., Longhini, Andrew P., Le Grice, Stuart F.J., Johnson, Bruce A., Dayie, Theodore K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766159/
https://www.ncbi.nlm.nih.gov/pubmed/28934505
http://dx.doi.org/10.1093/nar/gkx591