Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting as mutations, thereby increasing the overall genome stability. Defects in MMR are associated with increased cancer risk in humans and other or...

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Detalles Bibliográficos
Autores principales: Liu, Dekang, Frederiksen, Jane H., Liberti, Sascha E., Lützen, Anne, Keijzers, Guido, Pena-Diaz, Javier, Rasmussen, Lene Juel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766205/
https://www.ncbi.nlm.nih.gov/pubmed/28934474
http://dx.doi.org/10.1093/nar/gkx611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766205/
https://www.ncbi.nlm.nih.gov/pubmed/28934474
http://dx.doi.org/10.1093/nar/gkx611

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