Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells

Epithelial-mesenchymal-transition promotes intra-tumoral heterogeneity, by enhancing tumor cell invasiveness and promoting drug resistance. We integrated transcriptomic data for two clonal subpopulations from a prostate cancer cell line (PC-3) into a genome-scale metabolic network model to explore t...

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Detalles Bibliográficos
Autores principales: Marín de Mas, Igor, Aguilar, Esther, Zodda, Erika, Balcells, Cristina, Marin, Silvia, Dallmann, Guido, Thomson, Timothy M., Papp, Balázs, Cascante, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766231/
https://www.ncbi.nlm.nih.gov/pubmed/29293497
http://dx.doi.org/10.1371/journal.pcbi.1005914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766231/
https://www.ncbi.nlm.nih.gov/pubmed/29293497
http://dx.doi.org/10.1371/journal.pcbi.1005914

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