Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin

While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known. Here, we studied the ovarian and reproductive phenotypes in an Fmr1 knockout (KO) mouse model and the role...

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Detalles Bibliográficos
Autores principales: Mok-Lin, E., Ascano, M., Serganov, A., Rosenwaks, Z., Tuschl, T., Williams, Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766488/
https://www.ncbi.nlm.nih.gov/pubmed/29330421
http://dx.doi.org/10.1038/s41598-017-18598-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766488/
https://www.ncbi.nlm.nih.gov/pubmed/29330421
http://dx.doi.org/10.1038/s41598-017-18598-y

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