Cargando…

Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR

The mechanistic Target of Rapamycin (mTOR) signalling network is an evolutionarily conserved network that controls key cellular processes, including cell growth and metabolism. Consisting of the major kinase complexes mTOR Complex 1 and 2 (mTORC1/2), the mTOR network harbours complex interactions an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varusai, Thawfeek M., Nguyen, Lan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766521/ https://www.ncbi.nlm.nih.gov/pubmed/29330362 http://dx.doi.org/10.1038/s41598-017-18400-z

Ejemplares similares

Regulation of human mTOR complexes by DEPTOR
por: Wälchli, Matthias, et al.
Publicado: (2021)

Deptor: not only a mTOR inhibitor
por: Catena, Valeria, et al.
Publicado: (2017)

HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer
por: Doan, Hong, et al.
Publicado: (2019)

Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling
por: M. Gagné, Laurence, et al.
Publicado: (2021)

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
por: Heimhalt, Maren, et al.
Publicado: (2021)

Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
por: Cheng, Mengmeng, et al.
Publicado: (2016)

DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture
por: Xie, Qi-bing, et al.
Publicado: (2017)

Correction: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
por: Cheng, Mengmeng, et al.
Publicado: (2018)

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
por: González-Terán, Bárbara, et al.
Publicado: (2016)

miRNA‐182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury
por: Li, Yunsheng, et al.
Publicado: (2020)

Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway
por: Tian, Yun, et al.
Publicado: (2016)

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway
por: Hu, Binwu, et al.
Publicado: (2017)

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
por: Serrano-Maciá, Marina, et al.
Publicado: (2021)

Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway
por: Wang, W, et al.
Publicado: (2016)

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation
por: Vega, Mario, et al.
Publicado: (2022)

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression
por: Das, Falguni, et al.
Publicado: (2018)

Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network
por: Ghomlaghi, Milad, et al.
Publicado: (2021)

Ubiquitin chain specific auto‐ubiquitination triggers sustained oscillation, bistable switches and excitable firing
por: Nguyen, Lan K., et al.
Publicado: (2014)

Identification and Analysis of Differentially Expressed Genes in Human Saphenous Vein Endothelial Cells Overexpressing Domain-Containing mTOR-Interacting Protein (DEPTOR) by RNA-Seq
por: Wang, Wenjun, et al.
Publicado: (2019)

Role of mTOR Complexes in Neurogenesis
por: LiCausi, Francesca, et al.
Publicado: (2018)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

mTOR Inhibitors in Tuberous Sclerosis Complex
por: Curatolo, Paolo, et al.
Publicado: (2012)

Signaling crosstalk between the mTOR complexes
por: Xie, Jianling, et al.
Publicado: (2014)

mTOR-Dependent Spine Dynamics in Autism
por: Chaudry, Shabani, et al.
Publicado: (2022)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

DEPTOR in Skeletal Development and Diseases
por: Perez-Tejeiro, Jose Miguel, et al.
Publicado: (2021)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Dissecting the role of mTOR complexes in cellular senescence
por: Serrano, Manuel
Publicado: (2012)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

Elucidating the role of DEPTOR in Alzheimer’s disease
por: DAVIES, JULIE, et al.
Publicado: (2014)

Fine-Tuning of mTOR mRNA and Nucleolin Complexes by SMN
por: Gabanella, Francesca, et al.
Publicado: (2021)

Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy
por: Huan, Jianya, et al.
Publicado: (2022)

mTOR and lysosome regulation
por: Puertollano, Rosa
Publicado: (2014)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Targeting glutaminase and mTOR
por: Tanaka, Kazuhiro, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h51ic3ma053f9daa5ap430u7p0